Colchicine-Induced Rhabdomyolysis
نویسندگان
چکیده
A case of colchicine-induced rhabdomyolysis is reported. The 72-year-old man was hospitalized because of poor appetite, fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine for 5 months. Laboratory results revealed serum creatine kinase: 3627 IU/L, creatinine: 2.3 mg/dL, myoglobin: 1160.5 ng/mL (reference range: male: 17.4-105.7 ng/mL, female: 14.3-65.8 ng/mL) and urine myoglobin: 1689.6 ng/mL (reference range < 11.5 ng/mL). Polyphasic, fibrillation potential, positive sharp wave were noted on electromyography (EMG). A decrease in amplitude was noted in motor and sensory nerves on nerve conduction (NCV). EMG and NCV confirmed colchicine-induced rhabdomyolysis in our patient. Colchicine-induced rhabdomyolysis is a rare complication, and the postulated mechanisms and risk factors for this severe complication are discussed. (Acta Nephrologica
منابع مشابه
ADVERSE DRUG REACTION Colchicine induced rhabdomyolysis
A case of colchicine induced rhabdomyolysis is reported. A 73 year old man with ischaemic heart disease, atrial fibrillation, chronic congestive cardiac failure, and chronic gout presented with diVuse muscle pain. He had been taking an increased dose of colchicine (1.5 mg daily) for an exacerbation of gout for six weeks before the presentation. Investigations confirmed the diagnosis of rhabdomy...
متن کاملFatal colchicine overdose: report of a case and review of the literature.
Colchicine poisoning is an uncommon, but potentially life-threatening, toxicologic emergency. A case is reported of a 21-year-old woman who presented to the emergency department approximately 1 hour after ingesting 30 mg of colchicine in a suicide attempt. Her clinical course included gastrointestinal distress, metabolic acidosis, pancytopenia, hypotension, adult respiratory distress syndrome, ...
متن کاملColchicine-induced rhabdomyolysis following a concomitant use of clarithromycin in a haemodialysis patient with familial Mediterranean fever
Sir, Renal amyloidosis secondary to familial Mediterranean fever (FMF) is one of the common causes of nephrotic syndrome and chronic kidney disease in Turkey [1]. Colchicine is a microtubule-depolymerizing drug widely used for the treatment of gout which may prevent the development of secondary amyloidosis. In end-stage renal disease (ESRD), although the dose of colchicine is suggested to be re...
متن کاملAn Unexpected Interaction between Sofosbuvir/Ledipasvir and Atorvastatin and Colchicine Causing Rhabdomyolysis in a Patient with Impaired Renal Function
Hepatitis C virus (HCV) infection affects roughly 170 million people worldwide. Sofosbuvir/Ledipasvir (Sof/Led) is a new once daily direct acting antiviral combination pill that was approved in October 2014 for use in patients with HCV genotype 1 infection. Coadministration of Sof/Led is studied only with rosuvastatin which shows significantly increased level of drug and is associated with incr...
متن کاملResponse to the Letter entitled “The possible effect of colchicine on arteriovenous fistula maturation via neointimal hyperplasia blockage”
We would like to thank Drs. Eroglu and Kocyigit for their comment on possible use of colchicine on arteriovenous fistula maturation via neointimal hyperplasia blockage.1 We used simvastatin because it is a pleiotropic molecule capable of modulating the gene expression of vascular endothelial growth factor-A and matrix metalloproteinase-9. In our studies, simvastatin treated vessels had improved...
متن کامل